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  • Podquisition 214: Little Shop Of Horrors Without The Plant

    How do you do Little Shop of Horrors without the plant? One self-aggrandizing drama teacher tried it. Also, we wrap up 2018's games and look forward to 2019's games. As you do.

  • a16z Podcast: The Science and Business of Innovative Medicines

    with Vas Narasimhan (@vasnarasimhan), Jorge Conde (@jorgecondebio), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) On average, only 1 out of 20 medicines works when we actually bring them into the human body, and these rates of success haven't moved much in the pharma industry overall in the past 15 years, despite much scientific progress. Because if you really think about it, it's incredible that we find any human medicine that works at all, given that human beings are the product of billions of years of evolution, and represent an incredibly complex system we do not fully understand. Yet the business of the pharma industry -- and Novartis in particular, which covers everything from generics to innovative medicines -- is not that different from other large enterprises when it comes to managing R&D and pipelines of ideas, talent, and sales. So in this conversation, a16z bio general partners Jorge Conde and Vijay Pande with Sonal Chokshi interview Vas Narasimhan, CEO of Novartis. How does the world's largest producer of medicines in terms of volume -- 70. billion. doses. a. year. -- balance the science and the business of innovation? How does an enterprise at such vast scale make decisions about what to build vs. buy, especially given the fast pace of science today? How does it balance attitudes between "not invented here" and "not invented yet"? Narasimhan also takes us through the latest trends in therapeutics, such as cell and gene therapies (like CAR-T for cancer and more); RNA-based modalities; and others -- a sweeping tour from small molecules to large molecules to proteins and other modalities for making medicines. But where does tech come into all this, and where are we, really, on science becoming engineering? Why do both big companies and bio startups now need to get market value signals (not just approvals!) from payers earlier in the process of making therapeutics? And beyond all that, how could clinical trials be reinvented? Finally, what should all scientific (and all technical) leaders know when it comes to leadership? All this and more in this episode of the a16z Podcast, recorded recently on the road while at the J.P.M. health conference in San Francisco.

  • The Spin-off Doctors: Treasure Of The Four Crowns

    What can even be said about this hot nonsense? Treasure of the Four Crowns is a very special B movie in which dinosaur attacks barely warrant a mention and everything has to explode. It's a real... head turner.

  • a16z Podcast: Dark Data in Healthcare

    with Susannah Fox (@susannahfox), Anil Sethi (@anilsethiusa / @ciitizencorp), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) The problem of "dark data" in healthcare isn't just a feel-good empowerment thing, but a structural issue that leads to miscommunication and extra friction, different players in the entire healthcare system not being able to collaborate with each other, and just major missed opportunities all round. And yes, it also leads to lack of empowerment for patients, not to mention doctors too (who often have less than 30 minutes on site to do their jobs). But we already know all that. What's not clear is WHY and HOW is this the case, when the very point of HIPAA -- the Health Insurance Portability and Accountability Act (of 1996!) -- is to make data portable, not private. That is, IF patients know to ask for it... and can easily get it. So what if we could have a sort of permissioned "permissionless innovation" for healthcare data, not only bringing all that dark data to light, but more importantly -- borrowing from the history of internet innovation -- letting all sorts of expected and unexpected uses be built on top as a result? What happens when data and entities can talk to each other (à la APIs) through patients at the center of the circle of data? From the Dr. Google problem (or opportunity!) to clinical trials and even the opioid crisis, we -- Susannah Fox (former CTO of the U.S. Department of Health and Human Services); Anil Sethi (CEO and founder of Ciitizen); and a16z bio general partner Vijay Pande; in conversation with Sonal Chokshi -- explore all this and more in this episode of the a16z Podcast. Let there be light!

  • Episode 80 - Bungie & Activision Split Destiny?
    Gaming Illuminaughty

    No Clips Danny O Dwyer joins the join crew in episode 80 to talk Bungie, favorite games of 2018, OverWatch drama, The Epic Store and more!

  • 105 – Top 10 da CES 2019

    Mais um ano, mais uma CES! E como já é de costume, preparamos a nossa lista com as 10 novidades mais interessantes que vimos no evento. Aperta o play e vem com a gente! Participantes: - @mobilon - @paulohiga - @viviwerneck - @barbaaa

  • a16z Podcast: All About Synthetic Biology

    with James J. Collins, Vijay Pande (@vijaypande), and Hanne Tidnam (@omnivorousread) The idea of 'designing biology' -- once science fiction -- has over the last 20 years become just... science. In this episode, a16z bio general partner Vijay Pande with Hanne Tidnam talk all about the field of synthetic biology with James J. Collins, professor of bioengineering at MIT. Collins, whose work in synthetic biology and systems biology pioneered the field, has also launched a number of companies and received numerous awards and honors (including a MacArthur "Genius" Award, an NIH Director's Pioneer Award, and Sanofi-Institut Pasteur Award). This wide-ranging conversation about the birth of synthetic biology covers everything from the founding story of the discipline to what "engineering and designing" biology really looks like in action -- when instead of engineering electrons, you are engineering toggle switches for genes -- to the disciplinary differences (and synergies) between how biologists and engineers see the world. What are the engineering and design principles, techniques, approaches that work best when applied to science? How does building a company in this new space look different, in terms of platforms and products? And how is this new field changing education in science, all the way down to kits that allow you to play with the machinery of a cell... at home... and even in middle school?

  • a16z Podcast: What’s Next for Marketplace Startups (Hint: Services)

    The past and future of marketplace startups -- where are we? Ever since eBay popularized an internet meeting place for buyers and sellers of, well, just about everything, we’ve been waiting for 100 other at-scale marketplaces for everything else, including services. So in this hallway-style episode of the a16z Podcast (originally recorded as a video) Li Jin -- co-author with Andrew Chen of this post -- chats with a16z Deal & Research team operating partner about why there aren’t 100 thriving marketplaces for services yet... And what’s changing to make this next wave of marketplace startups super exciting.

  • Agent Janice SPEAKS - The WAN Show Jan 11 2019

    Savage Jerky: Use offer code LTT to save 10% on Savage Jerky at Freshbooks: For your unrestricted 30 days free trial, go to and enter in “The WAN Show” in the how you heard about us section. Private Internet Access: Sign up for Private Internet Access VPN at Forum Link: Apply to work at Floatplane Media: Floatplane Account Migration Details: Podcast Link: TBD Timestamps (Courtesy of Nightcore Prototype Zero) 0:00 starts to the JAN show 2:20 intro 3:02 ground rulez 3:26 Janice’s story 5:51 funny joke ( please laugh ) 8:16 Linus stops talking 9:06 best experience on pre-sale side 9:58 worst experience 12:37 tech support 16:36 new merch 18:00 what would Janice buy 25:33 floatplane questions 34:00 super chats 39:29 last question 42:27 last last question 47:00 Janice grabs Dennis and leaves (and her money) 47:45 SPONSORS WOO! (Denis runs in front of camera) 48:31 fresh books 49:18 PIA 49:38 SAVAGE jerky 51:54 CES talk 1:01:28 Denis on OLED 1:08:13 Linus shows new Hisense demo 1:12:16 end of JAN Show ( superchats ) 1:14:55 merch store and Luke is hiring 1:16:31 requirements 1:17:12 migration for floatplane 1:20:52 real end and Dennis waving underwear 1:21:01 outro

  • Runde #197: Lob, Tadel und Unverständnis
    Auf ein Bier GamesPodcast

    Sebastian wollte loben, tadeln und Unverständnis äußern, als wären wir englische Gouvernanten. Andre und Jochen waren sich sicher, dass sie zumindest zwei dieser Anforderungen erfüllen können. Und so ging’s los in eine wilde Folge über geliebte und gehasste Spielerfahrungen. Timecodes: 00:00 - Einführung 09:38 - Zeitlich begrenzte Demos 27:30 - Beeindruckende Demos 36:42 - Todesanimationen und Gore 53:56 - Lore in Rollenspielen und schlecht erklärte Spielsysteme 01:17:37 - Crafting und Inventory- Management 01:36:39 - Singleplayer- DLCs und ein drohender Plattformenkrieg auf dem PC

  • نشرة الأخبار… الثلاثاء 15 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • نشرة الأخبار… الأربعاء 16 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • نشرة الأخبار… الاثنين 14 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • 14.01 Digitund: kuidas uus ID-kaart kontaktivabalt tööle hakkaks?
    Geenius Raadio

    Eestis on juba üle 10 000 inimese, kel on uus ID-kaart. Miks see kaart mõnes kohas ei tööta, kuidas see võiks kontaktivabalt tööle hakata ja kas me võiks Eesti ID-kaardiga ka suurtesse välismaistesse platvormidesse sisse logida? Saate teemad: - Eesti kõige populaarsemad telefonid 2018 - miks Huawei töötaja Poolas pokri pisteti? - Apple'i laadimismatt ikkagi vist tuleb - mida asjalikku CESi messil näidati - uue ID-kaardid hädad ja võimalused Saatejuhid Hans Lõugas ja Henrik Roonemaa, külas Margus Arm riigi infosüsteemi ametist.

  • Has Wrestling Gone Too Far? - Dude Soup Podcast #208
  • نشرة الأخبار… الأحد 13 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • 241: Top 5 Independent Comics
    Geek History Lesson

    Marvel and DC aren't the only publishers making comic books. Stephen Schleicher (Major Spoilers, Critical Hit), returns to the podcast to break down our favorite Indie Comics! Be careful! This podcast contains SPOILERS. So if you don't want to know what happens, then you should come back later. Buy our Comic Book - JUPITER JET - right here: Get 50% off your first order and get started today for just $5! Visit and use promo code geekhistory. GET OUR RECOMMENDED READING from this episode here: Follow the show on TWITTER! Make sure to visit our Facebook fan page: You can find Ashley at and Jason at https://twitter.comJawiin. Thanks for showing up to class today. Class dismissed!

  • Gamekult l'émission #394 : 2019, ça sent l'année de transition ?
  • TMS 1632: Is it too early for a raccoon sandwich?
    Scott Johnson 24

    You like sauce or side? Does this look infected to you? Hmmm...Raccoon. Hi, it's your dad! R Kelly is hiding. Costco wants to hook you up for a gooey 20 years. Making Things With Bill and Jury Duty and more on this episode of The Morning Stream.

  • The Best of CES

    WIRED’s Gadget Lab team kicks off the new year with a wrap-up of the year’s biggest electronics show. Plus, an interview with Reddit’s Jen Wong.